Studies on dietary hypocholesterolemic agent in Briolers

Document Type : Original Article

Authors

1 Dept of Clinical Pathology , Fac. Vet. Med., Mansoura University.

2 Dept of Clinical Pathology, Fac. Vet. Med., Suez Canal University

3 Dept of Clinical Pathology, Fac. Vet. Med., Mansoura University.

4 Dept of Clinical Pathology , Fac. Vet. Med., Mansoura University

5 Dept. of Pathology, Fac. Vet. Med., Mansoura University

Abstract

In the present study, we evaluated and tested the hypocholesterolemic effect of statin (atorvastatin) in chickens. Thirty six (36) of one day old Cobb chicks were kept for 2 weeks for adaptation then divided into 3 equal groups each (12). Control (Gp.1) did not receive any treatment.GP-2 treated orally with 0.02% atorvastatin (0.2gm/kg ration). GP-3 treated orally with 0.05% atorvastatin ( 0.5gm/kg ration).Serum and whole blood sample were collected from all groups 2nd week and 4th week post treatment to evaluate some hematological and biochemical changes as well as immunomodulatory cytokines TNF-α, IL1β, and IL6. Oral treatment of the atorvastatin caused significant benefit results in chickens appeared in the correction of some biochemical parameters also try to stimulate cytokine response represents in TNF-α, IL1β, and IL6. From the present work, it could be concluded that statin (atorvastatin) has potent hypocholesterolemic effect, this appear in the correction with hematological, biochemical and immunological results.

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