Sameh, E., Elhady, K., srour, S., ELTarabili, R., Tahan, A., Abdou, R. (2023). Comparative Effect of Stevia and Aspartame Sweeteners: A biochemical,sero-biochemical, histochemical and Immunohistochemical Study. Suez Canal Veterinary Medical Journal. SCVMJ, (), -. doi: 10.21608/scvmj.2023.191622.1117
Eman Sameh; Kawther Elhady; sahar srour; Reham Mokhtar ELTarabili; Ahmed Tahan; Rania Helmy Abdou. "Comparative Effect of Stevia and Aspartame Sweeteners: A biochemical,sero-biochemical, histochemical and Immunohistochemical Study". Suez Canal Veterinary Medical Journal. SCVMJ, , , 2023, -. doi: 10.21608/scvmj.2023.191622.1117
Sameh, E., Elhady, K., srour, S., ELTarabili, R., Tahan, A., Abdou, R. (2023). 'Comparative Effect of Stevia and Aspartame Sweeteners: A biochemical,sero-biochemical, histochemical and Immunohistochemical Study', Suez Canal Veterinary Medical Journal. SCVMJ, (), pp. -. doi: 10.21608/scvmj.2023.191622.1117
Sameh, E., Elhady, K., srour, S., ELTarabili, R., Tahan, A., Abdou, R. Comparative Effect of Stevia and Aspartame Sweeteners: A biochemical,sero-biochemical, histochemical and Immunohistochemical Study. Suez Canal Veterinary Medical Journal. SCVMJ, 2023; (): -. doi: 10.21608/scvmj.2023.191622.1117
Comparative Effect of Stevia and Aspartame Sweeteners: A biochemical,sero-biochemical, histochemical and Immunohistochemical Study
Articles in Press, Accepted Manuscript, Available Online from 26 March 2023
2Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine,Suez Canal University, Ismailia 41522
3Biochemistry and Toxicology Department,Animal Health Research,Institute
4bacteriology,immunoloy and mycology department, faculty of veterinary medicine , Suez Canal University, Ismailia, Egypt
5Department of Pathology, Faculty of Veterinary Medicine,Suez Canal University, Ismailia 41522
6Forensic medicine and toxicology, Faculty of veterinary medicine, Suez canal university
Abstract
In the last few years, the market for sweeteners has grown tremendously. Aspartame is a common artificial sweetener that is thought to be dangerous. On the other hand, stevioside is a plant that includes sugar and was assumed to be a natural alternative to artificial sweeteners. Objectives: The objective of this study was to determine whether aspartame or stevioside affected biochemical,sero-biochemical, and immunohistochemical changes in adult rats following six weeks. Material and Methods: Forty-eight rats were used and divided into three groups: Group I: the control group, Group II: rats received aspartame (75 mg/kgday), Group III:rats received stevia (45 mg/kgday). All medications were given orally for 6 weeks. Lipid Peroxidation product (MDA); liver glutathione (GSH); Liver Superoxidase dismutase activity(SOD); catalase (CAT), Low-density lipoprotein (LDL) ; very low lipoprotein (VLDL) ;the cholesterol in the HDL;Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST); Creatinine, Urea, Total proteins were performed on blood and tissue specimens. Results: Aspartame group showed an increase in levels than the control group and stevioside-treated showed a decrease in levels than the control group aspartame had more harmful effects than stevia. Conclusion: Stevioside was less harmful than aspartame.
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