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Faheem, J., Eltarabili, R., El-Hady, K., Abdou, R. (2023). Ameliorating Effects of chrysanthemum Against Capecitabin in Albino Rats. Suez Canal Veterinary Medical Journal. SCVMJ, 28(1), 197-205. doi: 10.21608/scvmj.2023.307792
Jaklin Faheem; Reham Eltarabili; Kawther El-Hady; Rania H Abdou. "Ameliorating Effects of chrysanthemum Against Capecitabin in Albino Rats". Suez Canal Veterinary Medical Journal. SCVMJ, 28, 1, 2023, 197-205. doi: 10.21608/scvmj.2023.307792
Faheem, J., Eltarabili, R., El-Hady, K., Abdou, R. (2023). 'Ameliorating Effects of chrysanthemum Against Capecitabin in Albino Rats', Suez Canal Veterinary Medical Journal. SCVMJ, 28(1), pp. 197-205. doi: 10.21608/scvmj.2023.307792
Faheem, J., Eltarabili, R., El-Hady, K., Abdou, R. Ameliorating Effects of chrysanthemum Against Capecitabin in Albino Rats. Suez Canal Veterinary Medical Journal. SCVMJ, 2023; 28(1): 197-205. doi: 10.21608/scvmj.2023.307792

Ameliorating Effects of chrysanthemum Against Capecitabin in Albino Rats

Article 16, Volume 28, Issue 1, June 2023, Page 197-205  XML PDF (1.13 MB)
Document Type: Original Article
DOI: 10.21608/scvmj.2023.307792
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Authors
Jaklin Faheem* 1; Reham Eltarabili2; Kawther El-Hady3; Rania H Abdou3
1Veterinary Medicine Directorate, North Sinai Governorate
2Department of Bacteriology, Mycology and Immunity, Faculty of Veterinary Medicine, Suez Canal University
3Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University
Abstract
Our study was carried out to evaluate the effect of Chrysanthemum ethanolic extract on some hematological parameters in the anticancer drug capecitabine (XELODA®) exposed male rats using comet assay and biochemical changes. Thirty-six albino rats were divided into 6 groups (6 animals each) as follows:1) capecitabine group (xeloda at a dose of 30 mg/kg bw as a positive control); 2) capecitabine + chrysanthemum 5 mg/kg); 3) capecitabine (Xeloda) + Chrysanthemum (10 mg/kg); 4) Chrysanthemum (5 mg/kg) 5) Chrysanthemum (10 mg/kg); 6) Control group (negative control) for 45 days. The results of this study led to the following: capecitabine (Xeloda)treatment induces a decrease in RBCS, leukocytes, and platelets count, level of Hgb and Hct, while the use of capecitabine (Xeloda)in combination with Chrysanthemum improved these alterations, especially with the high dose of Chrysanthemum. Finally, the data suggest that the synchronous use of Chrysanthemum with capecitabine (Xeloda) treatment will be useful to decrease the side effects of capecitabine.
Keywords
Chrysanthemum; capecitabine; hematological parameters
Main Subjects
Bacteriology, Immunology and Mycology
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