Farouk, S., Ahmed, A., Hashem, M., Badran, S. (2023). Histological, Histochemical, and Immunohistochemical Studies on the Prostate Gland of Bilateral Castrated Dogs. Suez Canal Veterinary Medical Journal. SCVMJ, 28(2), 453-464. doi: 10.21608/scvmj.2023.244628.1150
Sameh M. Farouk; Amal A. M. Ahmed; Mohamed Hashem; Safa H. Badran. "Histological, Histochemical, and Immunohistochemical Studies on the Prostate Gland of Bilateral Castrated Dogs". Suez Canal Veterinary Medical Journal. SCVMJ, 28, 2, 2023, 453-464. doi: 10.21608/scvmj.2023.244628.1150
Farouk, S., Ahmed, A., Hashem, M., Badran, S. (2023). 'Histological, Histochemical, and Immunohistochemical Studies on the Prostate Gland of Bilateral Castrated Dogs', Suez Canal Veterinary Medical Journal. SCVMJ, 28(2), pp. 453-464. doi: 10.21608/scvmj.2023.244628.1150
Farouk, S., Ahmed, A., Hashem, M., Badran, S. Histological, Histochemical, and Immunohistochemical Studies on the Prostate Gland of Bilateral Castrated Dogs. Suez Canal Veterinary Medical Journal. SCVMJ, 2023; 28(2): 453-464. doi: 10.21608/scvmj.2023.244628.1150
Histological, Histochemical, and Immunohistochemical Studies on the Prostate Gland of Bilateral Castrated Dogs
1Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt
2Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
3Department of Surgery, Anaesthesiology and Radiology, Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
4Department of Cytology and Histology, Faculty of Veterinary Medicine, Arish University, North Sinai, Egypt.
Abstract
The prostate gland, an androgen-dependent organ, plays a pivotal role in male fertility. Bilateral castration, employed for therapeutic and preventive purposes in both humans and animals, prompted our investigation into the histological architecture of the prostate gland post-orchiectomy in adult male dogs. Six apparently healthy male mongrel dogs (18–20 kg, 12–24 months) were divided into Control and bilateral castrated groups. A blood testosterone test was conducted, and prostatic tissues were harvested on day 20 for basic histological, histochemical, and immunohistochemical studies. Results revealed a rapid decline in serum testosterone levels, concomitant with significant histological alterations in the prostate gland. Notably, there was a substantial reduction in epithelial height and a noticeable decrease in the immunostaining affinity of androgen receptors. Additionally, a marked interstitial thickening, characterized by a significant increase in the percentage of collagen fibers, was observed. In conclusion, bilateral castration induces changes in prostatic histological architecture alongside a depletion of blood testosterone levels. These findings contribute to our understanding of the impact of castration on male reproductive organs, potentially informing therapeutic and preventive strategies for androgen-dependent conditions.
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