Hematological Studies on the Effect of Some Agents Against Arthritis Induced in Rats

Articles in Press

Document Type : Original Article

Authors

1 Free Veterinarian, New Valley, Egypt

2 faculty of veterinary medecine department of clinical pathology

3 faculty of veterinary medecine departement of clinical pathology

Abstract

This study was designed to investigate the effect of formaldehyde-induced arthritis in rat model and evaluate the potency of flaxseed oil (FO) and graviola leaf extract (GrLE) as anti-arthritic agents. Sixty male albino rats were used in the study. They were randomly divided into 6 equal groups; Group I: Normal control rats received 0.9% saline (0.5 ml/kg b.wt) orally, Group II: Injected with FO at a dose of 3.0 ml/kg b.wt by i.p route, Group III: Received GrLE at a dose of 100 mg/kg b.wt orally, Group IV: Arthritic control group which induced to arthritis by sub planter injection of 0.1 ml of 2% formaldehyde solution v/v through the left hind paw on day 1 and day 3 of the experiment, Group V: Arthritic rats treated with FO, Group VI: Arthritic rats treated with GrLE. The results showed that arthritic untreated rats had signs of macrocytic hypochromic anemia. Also, they showed a significant leukocytosis, neutrophilia, lymphocytosis, monocytosis and eosinophilia. Moreover, they showed a significant thrombocytosis. However, arthritic rats treated with FO and GrLE showed improvement in the hematological parameters when compared to the arthritic untreated group. This suggested that FO and GrLE have anti-arthritic effect against formaldehyde-induced arthritis, likely due to their anti-inflammatory and antioxidant properties.

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Suez Canal Veterinary Medical Journal. SCVMJ

Articles in Press, Accepted Manuscript
Available Online from 08 April 2024

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