Document Type : Original Article
Authors
1
Professor of Pharmacology Faculty of Veterinary Medicine, Suez Canal University
2
Department of Botany and Microbiology, Faculty of Science, Suez Canal University, 41522 Ismailia, Egypt
3
Central Lab and Toxicology Research Unit, Faculty of Science, Suez Canal University, 41522, Ismailia, Egypt
Abstract
Over time, medicinal plants have been utilized to treat inflammation and related conditions. In traditional medicine, Suaeda sp is significant since it is used therapeutically. According to several investigations, they possess antioxidant, anticancer, and antibacterial effects. This study assessed the antioxidant and anti-inflammatory potential and activity of the leaves ethanolic extract of Suaeda vera in carrageenan-induced rat model at different doses (100 and 400 mg/kg doses, orally) for 5 h treatment. According to findings, the extract contains high antioxidant content and significant level of radical scavenging ability, quenching DPPH (1,1-diphenyl-2-picrylhydrazyl) radicals. Additionally, the extract included flavonoids and phenolics, as determined by the phytochemical screening. The in vivo anti-inflammatory study revealed inhibition of ethanolic extract of values of 13.39%, 28.75%, and 39.65%, at 100, 200 and 400 mg/kg doses, respectively. Diclofenac sodium, the positive control, demonstrated an inhibition value of 57.45 percent at a dose of 10 mg/kg. These findings show that S. vera has the potential to reduce inflammation, which supports the plant's ethnomedical claim.
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